Everything about U1 Spliceosomal Rna totally explained
U1 spliceosomal RNA is a
small nuclear RNA (snRNA) component of the
spliceosome (involved in pre-
mRNA splicing). Its 5' end forms
complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an
intron. There are significant differences in sequence and
secondary structure between
metazoan and
yeast U1 snRNAs, the latter being much longer (568
nucleotides as compared to 164 nucleotides in humans). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV.
[ This family doesn't contain the larger yeast sequences. ]
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